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. 2021 Aug 24;12:710608. doi: 10.3389/fimmu.2021.710608

Figure 1.

Figure 1

DNA damage, cell death and neuroplasticity markers in the injured cortex of young and aged mice. Western blot expression of cleaved-Fodrin (B), cleaved-PARP (C), phospho-c-Jun (D) and PSD95 (E) protein in the ipsilateral cortex young and aged Sham and TBI mice at 24 hours post-injury. Representative Western blots are shown in (A) TBI significantly increased cortical expression of cleaved-Fodrin (p<0.0001, B), cleaved-PARP (p=0.0075, C) and phosphor-c-Jun (p<0.0001, D) protein in young and aged mice. There was no effect of age on protein expression. TBI significantly decreased protein expression PSD95 (p<0.0001, E). There was no effect of age on PSD95 protein expression. Data expressed as Mean ± SEM. ***p < 0.001 vs. sham (effect of TBI). Two-way ANOVA using Tukey post-hoc tests (n=3-4/group).