Figure 4.

Expression of selected genes related to neuroinflammation, pattern recognition receptor, and response to viral infection. Selected transcripts were grouped by known or suspected functions related to neuroinflammation(A), pattern recognition receptors (B) and viral infection (C). Blue (cool colors) were used to graph low expression levels and orange (warmer colors) depict higher expression levels. For A-C, the heat map color scale reflects normalized log-transformed raw counts scaled to z-scores, where -1=darker blue=decreased expression and 1=darker yellow=increased expression. For most but not all transcripts, TBI increases expression. For some transcripts, TBI in aged mice shows the highest level of expression, but this age effect was not statistically significant for any transcript in the TBI only group.