Figure 5.

Interaction analysis of selected genes related to IFN-I signaling. Selected transcripts were grouped by known or suspected functions related to IFN-I signaling (A). For most but not all transcripts, TBI increases expression. For some transcripts, TBI in aged mice shows the highest level of expression, and this age effect was statistically significant for several transcripts. The heat map color scale reflects normalized log-transformed raw counts scaled to z-scores, where -1=darker blue=decreased expression and 1=darker yellow=increased expression. (B, C) GeneMania (http://www.genemania.org) was used to generate an expression interaction between genes represented in (A). Black nodes are the query genes (from A) and the connections/edges are colored based on interaction type, where (B) grey is for interactions between genes whose expression was altered (A, C) purple is for predicted interactions between genes in (A) (black nodes) and other genes (grey nodes) based on literature citations. The width of the edges is controlled by the evidence of the interaction, where thicker edges denote more evidence of interaction between the attached genes/nodes. Specific interaction values for each gene are shown in Supplemental Table 6.