Table 1.
Baseline Characteristics Stratified by Depressive Symptoms
| SCCOR (N=220) | COPDGene (N=745) | |||||
|---|---|---|---|---|---|---|
| Depressive Symptoms | ||||||
| Minimal | Elevated | p-value | Minimal | Elevated | p-value | |
| N | 173 | 47 | 648 | 97 | ||
| Age, mean (SD) | 67.2 (6.7) | 65.5 (6.5) | 0.12 | 69.6 (8.2) | 66.7 (8.5) | 0.002 |
| Gender | 0.51 | 0.19 | ||||
| Male | 99 (57.2%) | 24 (51.1%) | 359 (55.4%) | 61 (62.9%) | ||
| Female | 74 (42.8%) | 23 (48.9%) | 289 (44.6%) | 36 (37.1%) | ||
| BMI, mean (SD) | 27.8 (4.2) | 26.5 (3.5) | 0.04 | 26.2 (4.0) | 26.5 (4.1) | 0.53 |
| Active Smokers | 66 (38.2%) | 27 (57.4%) | 0.02 | 187 (28.9%) | 40 (41.2%) | 0.02 |
| BDI-II, median (IQR) | 4.0 (1.0, 6.0) | 14.0 (11.0, 16.0) | <0.001 | |||
| HADS-D, median (IQR) | – | – | 2.0 (1.0, 4.0) | 9.0 (8.0, 11.0) | <0.001 | |
| FEV1/FVC, mean (SD) | 58.1 (10.2) | 53.8 (10.6) | 0.01 | 53.0 (12.5) | 48.3 (13.5) | 0.002 |
| FEV1pp, mean (SD) | 71.2 (18.1) | 66.0 (18.4) | 0.09 | 61.8 (23.0) | 52.4 (23.2) | <0.001 |
| SGRQ, mean (SD) | 21.4 (15.4) | 38.1 (15.8) | <0.001 | 26.7 (18.5) | 49.3 (20.9) | <0.001 |
| SWD in feet, mean (SD) | 394.8 (139.5) | 372.7 (126.6) | 0.31 | |||
| 6MWD in feet, mean (SD) | 1254.2 (408.0) | 1045.6 (396.5) | <0.001 | |||
| IL-6, median (IQR) | 1.3 (0.9, 2.1) | 2.0 (1.0, 2.6) | 0.08 | 1.9 (1.2, 2.8) | 2.4 (1.5, 3.9) | 0.001 |
| Gold Stage | 0.01 | 0.002 | ||||
| I | 59 (34.1%) | 8 (17.0%) | 158 (24.4%) | 11 (11.3%) | ||
| II | 88 (50.9%) | 33 (70.2%) | 266 (41.0%) | 39 (40.2%) | ||
| III | 25 (14.5%) | 4 (8.5%) | 162 (25.0%) | 28 (28.9%) | ||
| IV | 1 (0.6%) | 2 (4.3%) | 62 (9.6%) | 19 (19.6%) | ||
Abbreviations: BMI, Body Mass Index; BDI-II, Beck Depression Inventory-II; HADS-D, Hospital Anxiety and Depression Score, Depression Subset; SGRQ, St. George’s Respiratory Questionnaire; SWD, Shuttle Walk Distance; 6MWD, Six Minute Walk Distance.