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. 2021 Aug 23;5(11):bvab143. doi: 10.1210/jendso/bvab143

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — The steroid synthesis pathway and photomicrographs of immunohistochemical labeling of steroid synthases in the resected tumor. The tumor was positive for steroidogenic acute regulatory protein (StAR), 21-hydroxylase, 11β-hydroxylase (CYP11β1), 17α-hydroxylase, DHEA-sulfotransferase (DHEA-ST), and 17β-hydroxysteroid dehydrogenase (HSD) 5 (17β-HSD5). The tumor was negative for 3β-HSD and 18-hydroxylase (CYP11β2). Blue dotted lines show related enzymes. Bold arrows mean “convertible” because of the existence of related enzymes. Dotted arrows mean “difficult to convert” because of low-level related enzymes. Scale bar: 100 μm. Abbreviations: DHEA: dehydroepiandrosterone, DOC: deoxycorticosterone.