Table 2.
Logistic Regression Analysis Demonstrating the Association Between Specific Analytes and Acute Retroviral Syndrome (ARS) Among Volunteers With Hyperacute HIV-1 Infection From Africa (Rwanda, Uganda, Zambia, and Kenya) and Sweden (N = 55)
| Analyte | Crude Coef. (95% CI) | P-value | Adjusted Coef. (95% CI)a | P-value |
|---|---|---|---|---|
| IL-12 | .24 (−.89 to 1.37) | .672 | … | … |
| IL-15 | .83 (−.98 to 2.64) | .355 | … | … |
| Eotaxin-3 | 3.20 (1.06–3.81) | <.001 | 3.57 (−.98 to 8.11) | .078 |
| IP-10 | 2.44 (1.07–3.81) | <.001 | 4.71 (.84 – 8.57) | .002 |
| Flt-1 | −.07 (−1.12 to .98) | .891 | … | |
| IFN-γ | 1.13 (.15 – 2.11) | .016 | 0.58 (-2.10 – 3.26) | .671 |
| IL-12p70 | 1.10 (−.44 to 2.64) | .161 | … | … |
| IL-13 | 1.39 (.14–2.63) | .020 | 1.37 (−1.77 to 4.51) | .379 |
Abbreviations: CI, confidence interval; Coef, coefficient; Flt, FMS-like tyrosine kinase; HIV-1, human immunodeficiency virus type 1; IFN, interferon; IL, interleukin; MSM, men who have sex with men.
aAdjusted for age group (18.0–24.9 vs >25.0 years), HIV-1 env subtypes (Non-A1 vs A1) and risk group (Non-MSM vs MSM).