Table 4.
Stratified Analysis Between rs769178 Polymorphisms and Allergic Rhinitis
| SNP | Case/Control | Heterozygous Model | Homozygous Model | Recessive Model | Dominant Model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs2228570 | GG | GT | TT | GT vs GG | P | TT vs GG | P | TT vs GT+GG | P | TT+GT vs GG | P |
| Gender | |||||||||||
| Females | 96/162 | 75/51 | 14/25 | 2.48(1.60–3.48) | <0.001 | 0.95(0.47–1.91) | 0.874 | 0.70(0.35–1.38) | 0.300 | 1.98(1.33–2.94) | 0.001 |
| Males | 205/231 | 177/89 | 33/42 | 2.24(1.63–3.08) | <0.001 | 0.89(0.54–1.45) | 0.628 | 0.66(0.41–1.06) | 0.086 | 1.81(1.35–2.41) | <0.001 |
| Age | |||||||||||
| ≤60 | 213/255 | 179/98 | 34/50 | 1.06(0.63–1.79) | 0.825 | 0.81(0.51–1.31) | 0.393 | 0.61(0.39–0.97) | 0.035 | 1.72(1.31–2.27) | <0.001 |
| >60 | 88/138 | 73/42 | 13/17 | 3.87(2.80–5.36) | <0.001 | 1.20(0.56–2.59) | 0.644 | 0.85(0.40–1.81) | 0.683 | 2.29(1.49–3.50) | <0.001 |
| Overweight | |||||||||||
| Yes | 114/102 | 85/40 | 13/22 | 1.90(1.20–3.02) | 0.006 | 0.53(0.25–1.10) | 0.086 | 0.42(0.21–0.87) | 0.016 | 1.41(0.93–2.14) | 0.101 |
| No | 187/291 | 167/100 | 34/45 | 2.60(1.91–3.54) | <0.001 | 1.18(0.73–1.90) | 0.510 | 0.83(0.52–1.33) | 0.448 | 2.16(1.63–2.86) | <0.001 |
| Smoking | |||||||||||
| Yes | 91/92 | 74/28 | 10/19 | 2.50(1.49–4.20) | <0.001 | 0.53(0.23–1.21) | 0.127 | 0.38(0.17–0.85) | 0.016 | 1.81(1.14–2.86) | 0.011 |
| No | 210/301 | 178/112 | 37/48 | 2.30(1.72–3.08) | <0.001 | 1.10(0.69–1.76) | 0.673 | 0.82(0.52–1.29) | 0.389 | 1.93(1.47–2.52) | <0.001 |
| Drinking | |||||||||||
| Yes | 71/104 | 58/34 | 12/23 | 2.50(1.49–4.20) | <0.001 | 0.76(0.36–1.63) | 0.487 | 0.56(0.27–1.17) | 0.118 | 1.80(1.13–2.85) | 0.012 |
| No | 230/289 | 194/106 | 35/44 | 2.30(1.72–3.08) | <0.001 | 1.00(0.62–1.61) | 0.998 | 0.74(0.47–1.18) | 0.205 | 1.92(1.47–2.51) | <0.001 |
| Family history | |||||||||||
| Yes | 109/81 | 87/31 | 18/15 | 2.09(1.26–3.44) | 0.004 | 0.89(0.42–1.87) | 0.762 | 0.69(0.33–1.41) | 0.305 | 1.70(1.08–2.66) | 0.021 |
| No | 192/312 | 165/109 | 29/52 | 2.46(1.82–3.33) | <0.001 | 0.91(0.56–1.48) | 0.693 | 0.66(0.41–1.06) | 0.082 | 1.96(1.49–2.58) | <0.001 |
| Asthma | |||||||||||
| Yes | 104/18 | 98/18 | 18/2 | 2.83(1.08–7.41) | 0.029 | 1.56(0.33–7.30) | 0.571 | 1.07(0.23–4.89) | 0.931 | 2.51(1.06–6.01) | 0.034 |
| No | 197/375 | 154/134 | 29/65 | 2.19(1.64–2.92) | <0.001 | 0.85(0.53–1.36) | 0.496 | 0.65(0.41–1.02) | 0.061 | 1.75(1.34–2.28) | <0.001 |