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. Author manuscript; available in PMC: 2021 Sep 7.
Published in final edited form as: ACS Nano. 2020 Oct 29;14(11):14528–14548. doi: 10.1021/acsnano.0c07581

Figure 7. SERS platform.

Figure 7.

a Detection process and design inspiration of the Au-coated TiO2 MIO SERS substrate. b SERS spectra of exosomes separated from plasma of different cancer patients and normal individuals. SERS intensity at 1,087 cm−1 is used for analysis. Reprinted with permission from ref. 47. Copyright 2020 American Chemical Society. c Multiplex exosome detection using SERS nanoprobes. Multiplexed capture probes were constructed by the co-modification of three types of aptamer DNAs. Followed by the recognition between aptamers and target exosomes, the SERS probes are released, and SERS signals are attenuated. d SEM images of the hybridized complexes of SERS probes–magnetic bead, and exosome-magnetic bead. e SERS spectra of the complexes obtained in the presence of single (left) and multiple (right) exosomes. Reprinted with permission from ref. 51. Copyright 2020 Royal Society of Chemistry.