Skip to main content
. Author manuscript; available in PMC: 2021 Sep 7.
Published in final edited form as: ACS Nano. 2020 Oct 29;14(11):14528–14548. doi: 10.1021/acsnano.0c07581

Figure 9. Subtyping of brain-derived exosomes reflecting brain diseases.

Figure 9.

a Detection and characterization of different brain-derived subpopulations of plasma exosomes by SPR imaging. b Sensorgram of exosome detection on the SPRi chip with spots of different antibodies. c SPRi intensities related to the injections of anti-CD81 and anti-GM1 in sequence for exosomes derived from blood plasma of five healthy subjects. Reprinted with permission from ref. 29. Copyright 2018 American Chemical Society. d Aβ proteins, the main component of amyloid plaques found in AD brain pathology, are released into the extracellular space. Through their surface glycoproteins and glycolipids, exosomes can associate with the released Aβ proteins. e Subtyping of circulating exosome-bound amyloid β using nanoplasmonics with periodic nanoholes. Correlations of different populations of circulating Aβ42 with global average PET brain imaging. When correlated to the global imaging data of brain amyloid plaque, the exosome-bound Aβ42 measurements demonstrated the best correlation. Reprinted with permission from ref. 34. Copyright 2019 Springer Nature. Creative Common CC-BY.