Table 2.
YSPDF improved the levels of various biochemical parameters in db/db mice.
| Biochemical parameters | NC | DKD | DKD+YSPDF |
|---|---|---|---|
| Final body weight (g) | 29.28 ± 2.74 | 46.42 ± 5.31### | 43.76 ± 3.21 |
| Kidney index (%) | 0.96 ± 0.11 | 1.33 ± 0.32## | 1.07 ± 0.42∗ |
| Fasting blood glucose (mmol/L) | 4.42 ± 0.74 | 23.78 ± 5.61### | 15.26 ± 4.64∗∗ |
| Serum creatinine (μmol/L) | 2.59 ± 0.41 | 5.52 ± 0.51### | 2.98 ± 0.87∗∗∗ |
| Urea nitrogen (mmol/L) | 6.01 ± 0.14 | 18.29 ± 4.11### | 9.36 ± 1.83∗∗ |
| 24 h urine protein (mg/L) | 1.37 ± 0.36 | 5.87 ± 1.54### | 1.96 ± 0.87∗∗∗ |
| Urine creatinine (mmol/L) | 2.42 ± 0.56 | 0.36 ± 0.12### | 0.81 ± 0.31∗∗∗ |
| Creatinine clearance (mL/min) | 1.82 ± 0.62 | 0.93 ± 0.15## | 1.46 ± 0.77∗∗ |
| Total cholesterol (mmol/L) | 3.86 ± 0.44 | 7.03 ± 0.91### | 4.66 ± 1.09∗∗∗ |
| Triglyceride (mmol/L) | 1.14 ± 0.41 | 3.68 ± 0.79### | 2.43 ± 0.49∗ |
| HDL (mmol/L) | 1.77 ± 0.35 | 1.07 ± 0.38# | 2.25 ± 0.75∗ |
| LDL (mmol/L) | 0.30 ± 0.11 | 0.51 ± 0.15# | 0.59 ± 0.47 |
NC refers to the normal control group; DKD refers to diabetic kidney disease group. Data were expressed as the mean ± SEM (n = 8). #p < 0.05, ##p < 0.01, and ###p < 0.001 compared with the normal control group; ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 compared with the DKD group.