Table 3.
Replication Analysis at Outcome Presentation Across HD Gene–Positive and HD Gene–Negative Groups
| Win > Lose Money |
Lose > Win Money |
Reward Prediction Error |
||||
|---|---|---|---|---|---|---|
| t | p | t | p | t | p | |
| Left VS | 5.67 | <.001 | Not tested | Not tested | 3.96 | .001 |
| Right VS | 6.19 | <.001 | Not tested | Not tested | 3.37 | .006 |
| Medial PFC | 5.52 | <.001 | Not tested | Not tested | 5.54 | <.001 |
| Bilateral Insula | Not tested | Not tested | 5.47 | <.001 | −6.02 | <.001a |
N = 70.
The table describes the 1-sided t statistic and corresponding p value testing whether activity in regions of interest, defined from existing literature, was positively associated with contrast at outcome presentation.
HD, Huntington's disease; PFC, prefrontal cortex; VS, ventral striatum.
a
Insula activity was positively associated with the punishment prediction error.