Table 2.
Results of neurological and functional testing according to histology and affected lesion location
| PA (n = 13) |
MB (n = 18) |
DN + (n = 15) |
DN − (n = 16) |
SCP + (n = 16) |
SCP − (n = 15) |
SCP + or DN + (n = 21) |
SCP − and DN − (n = 10) |
||
|---|---|---|---|---|---|---|---|---|---|
| Ataxia | ICARS total score | 4 (3)* | 9 (13.5)* | 11 (16) | 6 (5.3) | 13.5 (5.3)** | 4 (3)** | 9.0 (14) | 4.0 (3.3) |
| ICARS mean z-score | 1.4** | 9.7** | 13.8 | 5.8 | 17.2** | 2.4** | 9.8 | 3.2 | |
| Fine motor hand function | Drawing | ||||||||
| F | −0.72** | −1.61** | −1.36 | −1.10 | −1.9 | −0.8 | −1.3 | −1.5 | |
| NCV | 0.72** | 2.52** | 1.89 | 1.61 | 2.8* | 1.1* | 1.7 | 1.5 | |
| Writing sentence | |||||||||
| F | −0.6 | −1.05 | −1.41* | −0.35* | −1.1* | −0.3* | −1.0* | −0.1* | |
| NCV | 0.34 | 1.22 | 1.54* | 0.22* | 1.0** | −0.2** | 0.8* | −0.2* | |
| Intelligence | FSIQ | 102 (21) | 88 (22.5) | 88 (14) | 102 (24) | 87.5 (33)* | 102 (25)* | 88 (23.5)* | 103.5 (16.8)* |
| VIQ | 100 (19) | 93 (14.3) | 89 (25) | 100 (18) | 89 (27) | 100 (20) | 89 (21.5)* | 102 (13.3)* | |
| PIQ | 94 (27) | 86.5 (18.5) | 84 (9)* | 101 (26.3)* | 83 (15.8)* | 97 (27)* | 84 (13)** | 105.5 (19.5)** | |
| Planning | ToL | ||||||||
| acPRS | 24 (56) | 38.5 (51.3) | 24 (81) | 49.5 (51.3) | 28.5 (63) | 53 (67) | 24 (64.5) | 63 (44) | |
| Executive function | Baseline speed | −1.16** | −0.03** | −0.47 | −0.89 | 0.0** | −1.0** | −0.4 | −0.9 |
| Feature identification | |||||||||
| Dissimilar | −0.77 | −0.11 | 0.06 | −0.46 | 0.2 | −0.7 | −0.2 | −0.5 | |
| Similar | 0.80** | 0.92** | 0.16 | −0.07 | 0.2 | −0.2 | 0.1 | −0.2 | |
| Shifting attention | |||||||||
| Compatible fixed | −0.27** | 1.84** | 1.05 | 0.48 | 1.6* | 0.2* | 1.1 | 0.3 | |
| Incompatible fixed | 1.05 | 0.90 | 1.48 | 0.71 | 1.1 | 0.6 | 1.3 | 0.5 | |
| Compatible random | 0.63 | 1.34 | 1.02 | 0.97 | 1.4 | 0.9 | 1.3 | 0.4 | |
| Incompatible random | 0.28* | 1.28* | 0.90 | 0.59 | 1.3* | 0.3* | 1.2 | 0.2 | |
Median values and interquartile ranges (IQR)
PA pilocytic astrocytoma, MB medulloblastoma, DN + lesion in dentate nucleus DN − no lesion in dentate nucleus, SCP + lesion in superior cerebellar peduncle, SCP − no lesion in superior cerebellar peduncle, F frequency, NCV automation of fine motor hand function, FSIQ full scale intelligence quotient, VIQ verbal IQ, PIQ performance IQ, ToL Tower of London, acPRS age-corrected percentile rank score
*p < 0.05, **p < 0.01