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. 2021 Apr 17;70(10):3031–3040. doi: 10.1007/s00262-021-02935-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Impact of UPS tumor size on tumor infiltrating immune cells. a t-SNE plot analysis demonstrating T cell subsets, NK cells, myeloid, and granulocytes in the entire UPS cohort, UPS tumors < 8 cm, and UPS tumors > / = 8 cm. b Stacked bar graph depicting the relative fraction of immune cell subsets in the entire UPS cohort, UPS tumors < 8 cm, and UPS tumors > / = 8 cm. c Individual t-SNE channels demonstrating the expression of specific immune cell markers (HLA-DR, CD8, CD127, CD45RO, Ki-67). d Dot plot demonstrating the relationship between all CD8 + T cells and UPS tumor size. e Dot plot demonstrating the relationship between individual CD8 + T cell populations (effectors, naïve, and memory) and UPS tumor size. f Kaplan–Meier overall survival curve comparing UPS tumors with high CD8 + T cell expression to UPS tumors with low CD8 + lymphocyte expression. p-value, log-rank test