Fig. 4. Impaired intestinal lipid secretion in Bmal1^iKO mice.

a Serum ¹⁴C radioactivities in Bmal1^iKO and control mice after i.p. injection of [¹⁴C]-oleic acid. b ¹⁴C radioactivities in the tissues of Bmal1^iKO and control mice at 2 h after i.p. injection of [¹⁴C]-oleic acid. c Serum TAG levels in tyloxapol (500 mg/kg, i.p., 30 min)-pretreated Bmal1^iKO and control mice after olive oil gavage (10 μl/g). p values (from left to right): 0.3179, 0.0019, 0.0106, < 0.0001 and <0.0001 (two-way ANOVA and Bonferroni post hoc test). d Serum ³H-radioactivities in Bmal1^iKO and control mice after gavage of [³H]-triolein. p values (from left to right): 0.0716, 0.0004, <0.0001, <0.0001 and 0.0059 (two-way ANOVA and Bonferroni post hoc test). e ³H-radioactivities in the tissues and feces of Bmal1^iKO and control mice at 2 h after gavage of [³H]-triolein. Two-sided t test p values: 0.8101 (stomach), <0.0001 (small intestine), 0.0594 (colon), <0.0001 (liver), 0.0511 (heart), 0.0004 (BAT), <0.0001 (gWAT), <0.0001 (iWAT), <0.0001 (quadriceps), <0.0001 (soleus) and <0.0001 (feces). f Distribution of dietary TAG in the small intestine of Bmal1^iKO and control mice at 2 h after gavage of [³H]-triolein. p values (from left to right): <0.0001, 0.0040, 0.0009, <0.0001, 0.0008, 0.0015, 0.0002, 0.0246, 0.0895, 0.0842, 0.6833, 0.9999, 0.9278 and 0.1319 (two-way ANOVA and Bonferroni post hoc test). All data points are mean ± SD (n = 6 biologically independent samples). *represents a p value of < 0.05.