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. 2021 Sep 7;12:5321. doi: 10.1038/s41467-021-25684-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Heatmap of cut-and-run profiles of CARM1, H3K27ac, and input signal. Binding sites are sorted by strength of CARM1 signal. 3 kb around CARM1 peak centers are shown with 100 60 bp bins. b Genomic-wide distribution of CARM1 peaks relative to gene. c Ingenuity Pathway analysis of known regulators enriched among 7859 genes bound by CARM1. Transcriptional regulators with activation prediction Z-score of at least 2 and P < 0.001 are shown. The P value in Ingenuity Pathway analysis measures whether there is a statistically significant overlap between dataset genes and the genes that are regulated by a regulator. It is calculated using two-tailed Fisher’s Exact Test. d De novo motif analysis of 100 bp TSS regions for 7859 genes bound by CARM1. e Heatmap of cut-and-run profiles of XBP1s, CARM1, and input signal for vehicle (V) or ER stress-inducer tunicamycin (Tu)-treated cells around center of XBP1s peaks. Binding sites are sorted by strength of XBP1s signal. 3 kb around XBP1 peak centers are shown with 100 60 bp bins. f Correlation of XBP1s and CARM1 binding signal in XBP1s peak regions in tunicamycin-treated cells. P value was calculated using two-tailed test of significance. g Average profiles of binding signals for the indicated samples as shown in f.