Figure 1.

Bulk RNA-sequencing and Gene Set Enrichment Analysis (GSEA) pathway analysis. A: Samples from multiple organs were collected at the time of autopsy for Patient 1, a man in his 60s with a complex medical history and a long disease course. Reads mapping to the SARS-CoV-2 genome in unenriched host tissue were detected in nasopharynx and lung, whereas no reads were detected in olfactory bulb, prefrontal cortex, oropharynx, salivary gland, tongue, heart, liver, or kidney. Organ-specific data sets were grouped by infected-uninfected status for further analysis. B: Visualization of GSEA, showing the top four most statistically significant pathways. Nodes represent specific transcripts, and edges are color coded to reflect the pathways where the node is enriched. Nodes can have edges from multiple pathways. Illustration in A by Jill Gregory, reprinted with permission from © Mount Sinai Health System.