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. 2021 Sep 7;4:1046. doi: 10.1038/s42003-021-02587-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The significantly different metagenomic species among different time points. b Phylogenetic tree of the MAGs with clades colored by order. c MAGs of significant difference among different time points. d The intestinal microbial metabolic pathway that differed significantly between the samples at baseline and the samples with 6 months of methimazole treatment. e Genomic locations and contexts of SNPs in the species of Bacteroides xylanisolvens. These SNPs in Bacteroides xylanisolvens genome are mainly enriched in scaffold 19 and these genes related to the function of DNA-binding protein, conjugative transposon protein, and TraG family conjugative transposon ATPase.