Figure 2.

Structures of NTD and its antibody complexes.

(a) Cryo-EM structure of S1 fragment from the full-length SARS-CoV-2 S trimer (PDB ID: 6XR8), with the NTD highlighted in blue and the rest of S1 in gray. (b) Close-up view of the NTD in the SARS-CoV-2 S protein. (c) The NTD (in blue) from its complex with 4A8 is superposed with the domain from the full-length S trimer in gray, showing shifts of the five surface loops (N1–N5). (e) and (f) Close-up view of the binding interface for the NTD-4A8 and NTD-DH1205 complexes with contacting residues in the NTD highlighted in sticks. (d) Superposition of the structures of the NTD in complex with antibody 4A8 Fab (PDB ID: 7C2L; Ref. [28^••]) and DH1052 Fab (PDB ID: 7LAB; Ref. [32]), as indicated. Heavy and light chains of 4A8 are colored in red and pink, respectively, and those of DH1052 are in green and cyan, respectively.