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. 2021 Sep 8;50:173–182. doi: 10.1016/j.coviro.2021.08.010

Figure 3.

Figure 3

Structures of ACE2, ACE2-S complexes and RBD-antibody complexes.

(a) Cryo-EM structure of the full-length ACE2 in complex with BoAT1 (PDB ID: 6M17; Ref. [10]), with the peptidase domain (PD) of ACE2 in pink, its neck domain in magenta, the transmembrane helix in yellow, and BoAT1 in gray. (b) The side view (left) and the top view (right) of cryo-EM structure of the soluble S trimer complexed with three ACE2s (PDB ID: 7KJ4; Ref. [37]). (c) Left, the crystal structure of SARS-CoV-2 RBD in complex with ACE2 (PDB ID: 6M0J; Ref. [8••]), with ACE2 in pink and the RBD in cyan. Middle and right, close-up views of the binding interface with contacting residues from the N-terminal helix of the ACE2 and the RBM of the RBD shown in sticks. (d) Left, cryo-EM structure of the RBD in complex with antibody REGN10933 (PDB ID: 6XDG; Ref. [43••]). Middle, cryo-EM structure of the RBD in complex with antibody REGN10987 (PDB ID: 6XDG; Ref. [43••]). Right, crystal structure of the RBD in complex with antibody CR3022 (PDB ID: 6YLA; Ref. [45]). The RBD is shown in cyan and heavy and light chains of the antibodies in various colors. The RBM is highlighted in dark blue.