Table 1.
The list of differently expressed synaptosomal proteins between CSIS versus Control and CSIS + Tian versus CSIS. CSIS-chronic social isolation, Tian-tianeptine.
| Protein name | UniProtKB accession no | Gene | Ratio | Ratio |
|---|---|---|---|---|
| CSIS versus Control | CSIS + Tian versus CSIS | |||
| Inositol-1-monophosphatase | F1M978 | Impa1 | 3.86 | 1.35 |
| Phosphoglycerate mutase 1 | P25113 | Pgam1 | 3.77 | 2.14 |
| RAB33B, member RAS oncogene family | F1LW77 | Rab33b | 2.54 | 1.76 |
| Vesicle-associated membrane protein 2 | Q19LA7 | N/A | 2.34 | 1.85 |
| Ras-related protein Rab-2A | F1LP82 | Rab2a | 2.23 | 1.96 |
| Glutamate dehydrogenase 1, mitochondrial | P10860 | Glud1 | 2.07 | 1.32 |
| Uncharacterized protein | A0A0G2K099 | N/A | 2.00 | 1.34 |
| Pyruvate dehydrogenase E1 component subunit beta | A0A0G2KAM3 | Pdhb | 1.93 | 1.50 |
| Ras-related protein Rab-3A | P63012 | Rab3a | 1.89 | 1.41 |
| Pyruvate dehydrogenase E1 component subunit alpha | D4A5G8 | Pdha1l1 | 1.60 | 1.45 |
| Heat shock protein 86 | Q6B437 | N/A | 5.21 | 0.72 |
| Glucose-6-phosphate isomerase | Q6P6V0 | Gpi | 4.90 | 0.66 |
| Clathrin coat assembly protein AP180 | F1LRK0 | Snap91 | 4.22 | 0.39 |
| ATPase H + -transporting V1 subunit A | A0A1W2Q6N0 | Atp6v1a | 4.00 | 0.65 |
| Endophilin-A1 | O35179 | Sh3gl2 | 3.99 | 0.60 |
| Dynamin-1 | P21575 | Dnm1 | 3.89 | 0.63 |
| AP-2 complex subunit alpha | A0A0G2K943 | Ap2a2 | 3.63 | 0.50 |
| Fructose-bisphosphate aldolase | A0A0G2K3Q6 | Aldoc | 3.52 | 0.68 |
| Beta-enolase | P15429 | Eno3 | 3.51 | 0.71 |
| Phosphoglycerate kinase | M0R6Y8 | RGD1560402 | 3.46 | 0.71 |
| Alpha-1,4 glucan phosphorylase | G3V6Y6 | Pygb | 3.43 | 0.76 |
| Pyruvate kinase | A0A0G2JVG3 | Pkm | 3.30 | 0.75 |
| Aspartate aminotransferase, cytoplasmic | P13221 | Got1 | 3.29 | 0.78 |
| Protein kinase C and casein kinase substrate in neurons protein 1 | A0A0G2JWR2 | Pacsin1 | 3.23 | 0.74 |
| Aminopeptidase | F1M9V7 | Npepps | 3.20 | 0.67 |
| Guanine deaminase | Q9JKB7 | Gda | 3.19 | 0.75 |
| cAMP-dependent protein kinase type II-beta regulatory subunit | A0A0G2K5G0 | Prkar2b | 3.12 | 0.64 |
| Tubulin alpha chain | A0A0H2UHM7 | LOC100909441 | 3.07 | 0.59 |
| Tubulin beta-2A chain | P85108 | Tubb2a | 3.06 | 0.62 |
| Tubulin beta-5 chain | P69897 | Tubb5 | 3.00 | 0.63 |
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | P63329 | Ppp3ca | 2.83 | 0.69 |
| Septin 7 | D4A0F5 | Sept7 | 2.83 | 0.75 |
| Tubulin beta chain | G3V7C6 | Tubb4b | 2.74 | 0.71 |
| Septin 5 | D3ZT07 | Sep5 | 2.61 | 0.79 |
| Mitogen-activated protein kinase 1 | P63086 | Mapk1 | 2.53 | 0.74 |
| Spectrin alpha chain, non-erythrocytic 1 | A0A0G2K1Y8 | Sptan1 | 2.44 | 0.73 |
| ATPase, H + transporting, V1 subunit E isoform 1, isoform CRA_a | G3V7L8 | Atp6v1e1 | 2.39 | 0.66 |
| Vesicle-fusing ATPase | A0A0G2K6U1 | Nsf | 2.32 | 0.64 |
| Contactin-1 | Q63198 | Cntn1 | 2.11 | 0.75 |
| Syntaxin-binding protein 1 | P61765 | Stxbp1 | 1.99 | 0.77 |
| Spectrin beta chain | G3V6S0 | Sptbn1 | 1.96 | 0.75 |
| Tenascin-R | F1LQ63 | Tnr | 1.84 | 0.58 |
| Neurofascin | D3ZW56 | Nfasc | 1.59 | 0.71 |
Proteins were identified according to MS/MS spectra search against the Uniprot/Swissprot database using the Proteome Discoverer (version 1.3) search engine (Thermo Fisher Scientific).