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. 2021 Sep 7;7:235. doi: 10.1038/s41420-021-00610-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The target genes of miR-199a-3p were predicted through TargetScan and Starbase databases. B The binding site between miR-199a-3p and SP1 was predicted through the Starbase database. C The binding relationship between miR-199a-3p and SP1 was verified using dual-luciferase assay. D RNA immunoprecipitation of Ago2 antibody by MAEC lysate. E miR-199a-3p expression in each group was detected using qRT-PCR. F SP1 expression in each group was detected using western blot. G SP1 expression in MAECs after EPC-EVs treatment was detected using western blot. Each experiment was repeated three times independently. Measurement data are depicted as mean ± SD. The t test was used for the comparisons between two groups. One-way ANOVA was employed for the comparisons among multiple groups, followed by Tukey’s multiple comparisons test. *p < 0.05.