Fig. 4.

Effects of DFP on tau pathology. a, c Stereological estimates of AT8-labeled tau in the hippocampus and cortex (2-tailed t test). Ratios of p-tau/total tau in soluble hippocampus fractions (b, one-way ANOVA, Tukey’s post hoc test; d, 2-tailed t test). e, Ratios of p-tau/total tau in insoluble hippocampus fractions (2-tailed t test). f, Representative western blot images (note, some antibodies were probed on the same stripped blots used in Fig. 4 and Fig. 5) of total and p-tau in the hippocampus. Ratios of p-tau/total tau were determined using normalized ß-actin or GAPDH values. Error bars represent±SEM. TgSSV, vehicle-treated rTg4510 mice; TgDFP, DFP-treated rTg4510 mice. n=6/group; * p<0.05