Comparison of EDSS score changes in patients with AQP4-IgG positive, first attack, LETM, and IVMP treatment. (A) Median EDSS score of the NE group was lower in AQP4-IgG-positive patients at 6 month (n = 33). (B) EDSS improvement in the PE group was less than that in the NE group in patients who experienced first attack (n = 25). (C) In patients with transverse myelitis, EDSS improved poorly in the PE group compared with the NE group (n = 30). (D) In patients treated only with IVMP, 6-month median EDSS score was lower in the NE group (n = 33). *p < 0.05 and **p < 0.01.