Fig. 2.

Time-dependent SUVR plots provide a means to assess the temporal stability of SUVR measurements, can help identify an optimal static scanning window, and can highlight instances where deviations in acquisition time might contribute to additional variability. (a) Schematic showing the ideal case where a quasi-steady-state of SUVR(t) is obtained at a certain time post-injection. (b) Average SUVR(t) curves across small cohorts of subjects at different disease stage for [¹⁸F]flortaucipir in the lateral temporal lobe, indicating that a quasi-steady-state is not achieved (on average) in more advanced disease stages. (c) SUVR(t) curves from a single Alzheimer’s disease individual using [¹⁸F]PI-2620, where each color represents a different brain region, indicating that a quasi-steady-state is not achieved in regions with higher tau burden (a was originally published in the Journal of Cerebral Blood Flow and Metabolism [130]© SAGE Publishing; b was originally published in the Journal of Nuclear Medicine [131] © SNMMI; c was originally published in the Journal of Nuclear Medicine [96] © SNMMI)