Fig. 2.

Antemortem structural MRI macrostructural features of a brain donor with autopsy-confirmed CTE. This is an 85-year-old, White, male brain donor with autopsy-confirmed CTE who is from the Veteran Affairs (VA)-Boston University (BU)-Concussion Legacy Foundation (CLF) brain bank and part of the UNITE study. He was an elite American football player. The MRI was obtained via medical record requests and was completed during life as part of clinical care when he was 82 years old. He had a Functional Activities Questionnaire (FAQ) score of 19/30, and a panel of clinicians from the UNITE study determined he had dementia prior to death. Cause of death was cardiovascular disease, and the donor had a history of hypertension and diabetes. The brain donor was neuropathologically diagnosed with stage IV CTE and had no other neurodegenerative disease diagnoses. The MRI shows (a) global atrophy most prominent for the frontal and temporal lobes on axial T1 as well as a posterior cavum septum pellucidum, (b) bilateral medial temporal lobe atrophy on coronal T1, and (c) and moderate microvascular disease on FLAIR