Fig. 1.

Least squares mean change in outcome measures from baseline to week 8 in participants receiving reldesemtiv at doses of (A) 150 mg bid, and (B) 450 mg bid compared with placebo. *LSM change on reldesemtiv minus LSM change on placebo for all measures except TUG and SMA-HI, which are LSM change on placebo minus LSM change on reldesemtiv. bid = twice daily; FVC = forced vital capacity; HFMS-E = Hammersmith Functional Motor Score-Expanded; LSM = least squares mean; MEP = maximum expiratory pressure; MIP = maximum inspiratory pressure; pbo = placebo; RULM = revised upper limb module; SMA-HI = Spinal Muscular Atrophy-Health Index; TUG = timed up and go