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Schematic representation illustrating the common molecular pathways between endothelial and oligodendrocyte dysfunction and obstructive sleep apnea. Oxidative stress could increase the activity of metalloproteinases (MMPs) and NADPH oxidases (NOXs). The extracellular protein matrix and tight junctions are degraded by MMPs, which contributes to endothelial and oligodendrocyte dysfunction. The NOX activity provokes increased ROS levels in a positive feedback loop.
