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Effects of β-PAE on AQP3 expression and PKA/CREB signaling pathway in IEC-6 cells. Cell viability following treatment with different doses of (A) 5-FU for 24 and 48 h and (B) β-PAE for 24 and 48 h; (C) β-PAE enhanced 5-FU-injured cell viability; (D,E) AQP3 expression; (F,G) PKA, p-MEK1/2, MEK1/2, p-MSK1, MSK1, p-CREB, and CREB expression. Data are shown as mean ± SD (n = 3). ## p < 0.01 versus control group; * p < 0.05, ** p < 0.01 versus 5-FU group.
