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. 2021 Aug 25;12:689491. doi: 10.3389/fphar.2021.689491

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Copyright © 2021 Wu, Gan, Luo, Xu, Chen, Li, Guan, Su, Lin, Xie and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of β-PAE on mucus layer. (A) MUC2 mucin protein and goblet cells in the small intestine (magnification 100x), the arrows indicate positive protein expression; (B) IOD of MUC2 mucin expression; (C) The number of goblet cells; Spearman’s correlation analysis (D) between MUC2 mucin protein expression and inflammatory cytokines level; (E) between goblet cells and inflammatory cytokines level; (F) between MUC2 mucin expression and diarrhea symptoms; and AQP3 levels; (G) between goblet cells and diarrhea symptoms; and AQP3 levels. Data are shown as mean ± SD (n = 6). ^## p < 0.01 versus control group; ^* p < 0.05, ^** p < 0.01 versus 5-FU group.