TABLE 3.

Model selection and development.

Model description		OFVa	ΔOFVb	AICc
One-compartment mode		465.41	—	471.41
Two-compartment model		465.41	—	475.41
The choice of residual variability model (One-compartment model)
Addictive error model		402.93	—	412.93
Proportional error model		375.14	—	385.14
Combined error model		375.15	—	387.14
Full covariate model		363.90	11.24	375.90

^aobjective function value.

^bchange in objective function value in the covariate model.

^cAkaike information criterion.