Figure 1.

METTL3 overexpression inhibits viability and tumor growth

(A) Immunohistochemistry of METTL3 in cervical cancer tissues (original magnification, ×100). (B) METTL3 protein levels in different cervical cancer cells were detected by western blotting. (C) METTL3 protein expression was detected in SiHa cells and C33A cells after METTL3 overexpression or knockout. (D) The cell viability in cells with METTL3 overexpression or knockout was analyzed by a CCK-8 assay. ∗p < 0.05, ∗∗∗p < 0.001 versus vector or NC group. (E) Overexpression of METTL3 inhibited tumor growth. (F) Tumor volumes were measured and calculated (left panel). Body weights were measured and calculated (right panel). ∗∗p < 0.01, ∗∗∗p < 0.001 versus vector group. KO, knockout; NC, negative control; OE, overexpression.