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. 2021 Jun 4;22:245–255. doi: 10.1016/j.omto.2021.05.013

Figure 3.

Figure 3

METTL3 regulates RAGE expression in cervical cancer

(A) Immunohistochemistry of METTL3 and RAGE in cervical cancer tissues (original magnification, ×100). (B) Immunofluorescence double staining of METTL3 and RAGE in cervical cancer tissues (original magnification, ×100). (C) The expression of METTL3 and RAGE in SiHa cells after METTL3 modulation was detected by western blotting. (D) SiHa cells with RAGE overexpression were observed under the bright field of a microscope, and their fluorescence (GFP) was observed under the dark field of a microscope (original magnification, ×100). (E) The expression levels of LRP1 and MRP1 were detected in RAGE-overexpressing SiHa cells by western blotting. (F) Chemotherapeutic sensitivity of cisplatin in SiHa cells with RAGE overexpression was analyzed by a CCK-8 assay. ∗∗p < 0.01, ∗∗∗p < 0.001 versus vector group.