Table 1.
Demographic, clinical and laboratory data of COVID-19 ICU patients (BSIs and non-BSIs group)
| Parameters | All patients (n = 750) | Patients with BSIs (n = 64) | Non-BSIs (n = 686) | p value |
|---|---|---|---|---|
| Age (median) | 62 years (IQR 51–72) | 65 years (IQR 54–70) | 60 (IQR 48–69) | 0.31 |
| (Mean ± SD) | 60 ± 17.71 years | 61.32 ± 13.74 years | 59.13 ± 16.88 years | |
| Male (%) | 562 (75) | 42 (65.6) | 487 (71) | 0.37 |
| q SOFA Score (median) | 2 | |||
| Comorbidities and risk factors (%) | ||||
| Comorbidities# | 317 (42.3) | 44 (70) | 273 (39.7) | 0.01 |
| Hypertension | 183 (24.4) | 32 (50) | 151 (22) | |
| Diabetes mellitus | 207 (27.6) | 28 (43.8) | 179 (26) | |
| Ischemic heart diseases | 67 (8.9) | 7 (10.9) | 60 (8.7) | |
| Immunosuppressants use | 64 (8.5) | 9 (10.9) | 55 (8) | |
| CKD/ESRD$ | 40 (5.3) | 6 (9.4) | 34 (5) | |
| Hypothyroidism | 47 (6.3) | 5 (7.8) | 42 (6.1) | |
| Stroke | 41(5.5) | 4 (6.4) | 37 (5.4) | |
| COPD | 29 (3.9) | 2 (3.2) | 27 (3.9) | |
| Rheumatoid arthritis | 23 (3.1) | 2 (3.2) | 21 (3.0) | |
| Chronic liver disease | 29 (3.9) | 1 (1.6) | 28 (4.1) | |
| Invasive devices (insitu), (%) | ||||
| Foleys Catheter | 485 (64.7) | 46 (71.9) | 439 (64) | 0.20 |
| Endotracheal intubation | 137 (18.3) | 44 (68.8) | 93 (13.6) | 0.001 |
| Arterial line | 282 (37.6) | 21 (32.8) | 261 (38) | 0.24 |
| Central venous line | 251 (33.5) | 17 (26.6) | 234 (34.1) | 0.31 |
| Laboratory parameters, median (IQR) | ||||
| Hb (g/dl) | 11.1 [8.8–12.9] | 10 [8.25–12] | 11. 3 [8.45–13.1] | 0.51 |
| Total leukocyte counts (103/μl) | 10.7 [7.73–15.91] | 16.5 [11.2–22.8] | 10.7 [7.73–15.91] | 0.001 |
| Platelet count (103/μl) | 247 [161–350] | 198 [111–341] | 273 [198–362] | 0.10 |
| CRP (mg/L) | 100 [40.2–145.7] | 128 [97–171] | 96.1 [39.1–139.8] | 0.06 |
| Procalcitonin (ng/ml) | 0.92 [0.145–6.99] | 5 [1.75–15.5] | 0.19 [0.09–1.12] | 0.02 |
| AST (IU/L) | 48 [30–129] | 44 [29–134] | 49 [31–135] | 0.73 |
| ALT (IU/L) | 37 [22–89] | 42 [26–92] | 36 [21–89] | 0.60 |
| Blood urea nitrogen (mg/dl) | 48.5 [31–99.25] | 100 [56–130] | 35 [22–62] | 0.002 |
| Creatinine (mg/dl) | 1.1 [0.84–1.8] | 2 [1–3] | 1.04 [0.84–1.5] | 0.01 |
| Bacterial microorganism identified in blood-stream | ||||
| Acinetobacter baumannii | 21 (32.8) | |||
| Klebsiella pneumoniae | 14 (21.9) | |||
| Enterococcus spp. | 11 (17.2) | |||
| Escherichia coli | 7 (10.9) | |||
| Burkholderia cepaciae complex | 4 (6.3) | |||
| Pseudomonas aeruginosa | 4 (6.3) | |||
| Elizabethkingia spp. | 3 (4.7) |
q SOFA Quick Sequential Organ Failure Assessment; CKD/ESRD chronic kidney disease/End stage renal disease; COPD chronic obstructive pulmonary disease; Hb hemoglobin; CRP C reactive protein; ALT alanine aminotransferase; AST aspartate aminotransferase
#Some patients had more than one comorbid state
$Out of 40 patients, 14 patients needed hemodialysis support