Table 2.
List of potential drugs for SARS-CoV-2 infection based on the network cluster analysis
| Clusters | SARS-CoV-2 gene | SR gene | Drug | Interaction types |
|---|---|---|---|---|
| Cluster A | S, E, M, N, ORF7a | C3 | Zinc chloride | Inhibitor, ligand |
| C3 | Methyldopa | Unknown | ||
| S, E, N, ORF3a | C1R | Zinc chloride | Modulator | |
| C1R | Methyldopa | Unknown | ||
| S, E, N, ORF3a | C1S | Zinc chloride | Modulator | |
| C1S | Methyldopa | Unknown | ||
| S, E, M, N, ORF3a | CFB | Methyldopa | Unknown | |
| Cluster B | S, E, M | PSMB3 | Bortezomib | Inhibitor |
| PSMB3 | Carfilzomib | Inhibitor | ||
| PSMB3 | Ixazomib citrate | Inhibitor | ||
| S, E, N, ORF1ab, ORF3a | PSMC5 | Carfilzomib | Inhibitor | |
| PSMC5 | Bortezomib | Inhibitor | ||
| PSMC5 | Ixazomib citrate | Inhibitor | ||
| M, ORF1ab, ORF7a, ORF8 | PSMC3 | Carfilzomib | Inhibitor | |
| PSMC3 | Bortezomib | Inhibitor | ||
| PSMC3 | Ixazomib citrate | Inhibitor |