Table 2.

The paths of targeted reconstruction of tumor stroma.

Target	Path
TVEC	The normalization of tumor vasculature
ECM	Inhibiting of collagen synthesis
	Degradation of stromal collagen
	Hyaluronic acid as a therapeutic target
	Treatment of hypoxia
CAFs	Paracrine pathway
	Remodeling ECM
	Promoting tumor angiogenesis
	Targeting CAFs to normalize tumor stiffness
	Reprogramming CAFs to an immunosupportive state

TVEC, tumor vascular endothelial cells; ECM, extracellular matrix; CAFs, cancer-associated fibroblasts.