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Scheme of siRNA-loaded PEGylated NPs that shows reduced non-specific interactions with blood proteins at physiological pH. However, at the slightly acidic pHe, PEG molecules are removed from the surface of the NPs because of their acid-cleavable DMMA linker, promoting the intracellular delivery of the siRNA. Reprinted with permission from Ref. 106. Copyright © 2012 American Chemical Society.
