Table 2.

Na⁺/H⁺ exchangers (NHE) in cancer.

Cancer	NHE1	NHE2	NHE3	NHE3R1	NHE3R2	NHE4	NHE5	NHE6	NHE7	NHE8	NHE9
Adrenal gland	n/a	22.78	1.27	2.53	8.86	15.19	5.06	35.44	11.39	32.91b	2.53
Breast	2.54	5.62	5.89	15.49	7.88	1.9	3.8	10.14	5.89	15.49	3.35
CNS	4.59	4.59	4.45	4.73	3.59	6.31	3.73	6.31	2.58	7.03	4.3
Cervix	3.58	3.58	4.56	7.17	2.93	1.63	9.45	22.8	6.31	8.79	11.07
Endometrium	3.16	3.16	4.32	3.82	5.48	3.65	9.3	5.81	8.47	8.31	3.65
Hematop. & Lymph.	4.07	1.36	3.62	4.07	4.07	5.43	6.33	4.07	4.52	4.07	2.71
Kidney	4.33	3.33	5.67	4	6.33	0.83	7	7.33a	8a	4.17	5
Large intestine	2.46	4.92	5.57	4.26	7.05	3.28	7.05	12.46	9.84	24.92	4.1
Liver	3.22	2.95	3.22	16.89	2.95	3.49	5.36	15.28	8.58	5.36	3.75
Lung	2.36	7.16	4.32	4.91	3.53	5.4	6.38	9.62	8.73	5.4	10.11
Oesophagus	7.2	4	4	10.4	2.4	3.2	25.6	6.4	1.6	44.01	10.4
Ovary	1.5	3.38	13.53	7.52	2.26	7.52	0.38	8.65	3.38	5.64	1.13
Pancreas	3.35	9.5	5.59	6.15	6.15	6.7	4.47	12.29	1.12	6.15	4.47
Prostate	3.82	4.82	2.21	5.22	5.62	4.62	3.01	n/a	n/a	3.41	6.22
Skin	4.44	0.85	7.61	2.75	2.96	2.96	9.73	7.4	16.28	14.8a	2.54
Soft tissue	6.84	6.08	1.52	3.04	2.28	3.8	4.56	0.76	18.25	12.93	6.46
Stomach	4.56	11.93	11.23	7.37	5.26	7.72	5.96	6.32	11.93	16.84	2.46
Thyroid	3.51	3.12	0.19	3.9	5.46	0.58	1.95	4.87	3.31	2.53	3.51
Upper aerodig. tract	5.56	3.07	4.98	6.13	5.75	2.87	5.56	7.85	4.6	5.75	10.92
Urinary tract	4.17	8.82	3.92	5.39	4.17	9.8	7.84	3.92	6.13	11.76	2.7

Overexpression levels of the Na⁺/H⁺ exchanger (NHE) family members in cancer affecting several tissues.

Asterisks: also downregulated in some patients.

Overexpression >20% in bold letters.

n/a, not available.

^a(5%–10%).

^b(10%–15%).