Table 2.
Cancer | NHE1 | NHE2 | NHE3 | NHE3R1 | NHE3R2 | NHE4 | NHE5 | NHE6 | NHE7 | NHE8 | NHE9 |
---|---|---|---|---|---|---|---|---|---|---|---|
Adrenal gland | n/a | 22.78 | 1.27 | 2.53 | 8.86 | 15.19 | 5.06 | 35.44 | 11.39 | 32.91b | 2.53 |
Breast | 2.54 | 5.62 | 5.89 | 15.49 | 7.88 | 1.9 | 3.8 | 10.14 | 5.89 | 15.49 | 3.35 |
CNS | 4.59 | 4.59 | 4.45 | 4.73 | 3.59 | 6.31 | 3.73 | 6.31 | 2.58 | 7.03 | 4.3 |
Cervix | 3.58 | 3.58 | 4.56 | 7.17 | 2.93 | 1.63 | 9.45 | 22.8 | 6.31 | 8.79 | 11.07 |
Endometrium | 3.16 | 3.16 | 4.32 | 3.82 | 5.48 | 3.65 | 9.3 | 5.81 | 8.47 | 8.31 | 3.65 |
Hematop. & Lymph. | 4.07 | 1.36 | 3.62 | 4.07 | 4.07 | 5.43 | 6.33 | 4.07 | 4.52 | 4.07 | 2.71 |
Kidney | 4.33 | 3.33 | 5.67 | 4 | 6.33 | 0.83 | 7 | 7.33a | 8a | 4.17 | 5 |
Large intestine | 2.46 | 4.92 | 5.57 | 4.26 | 7.05 | 3.28 | 7.05 | 12.46 | 9.84 | 24.92 | 4.1 |
Liver | 3.22 | 2.95 | 3.22 | 16.89 | 2.95 | 3.49 | 5.36 | 15.28 | 8.58 | 5.36 | 3.75 |
Lung | 2.36 | 7.16 | 4.32 | 4.91 | 3.53 | 5.4 | 6.38 | 9.62 | 8.73 | 5.4 | 10.11 |
Oesophagus | 7.2 | 4 | 4 | 10.4 | 2.4 | 3.2 | 25.6 | 6.4 | 1.6 | 44.01 | 10.4 |
Ovary | 1.5 | 3.38 | 13.53 | 7.52 | 2.26 | 7.52 | 0.38 | 8.65 | 3.38 | 5.64 | 1.13 |
Pancreas | 3.35 | 9.5 | 5.59 | 6.15 | 6.15 | 6.7 | 4.47 | 12.29 | 1.12 | 6.15 | 4.47 |
Prostate | 3.82 | 4.82 | 2.21 | 5.22 | 5.62 | 4.62 | 3.01 | n/a | n/a | 3.41 | 6.22 |
Skin | 4.44 | 0.85 | 7.61 | 2.75 | 2.96 | 2.96 | 9.73 | 7.4 | 16.28 | 14.8a | 2.54 |
Soft tissue | 6.84 | 6.08 | 1.52 | 3.04 | 2.28 | 3.8 | 4.56 | 0.76 | 18.25 | 12.93 | 6.46 |
Stomach | 4.56 | 11.93 | 11.23 | 7.37 | 5.26 | 7.72 | 5.96 | 6.32 | 11.93 | 16.84 | 2.46 |
Thyroid | 3.51 | 3.12 | 0.19 | 3.9 | 5.46 | 0.58 | 1.95 | 4.87 | 3.31 | 2.53 | 3.51 |
Upper aerodig. tract | 5.56 | 3.07 | 4.98 | 6.13 | 5.75 | 2.87 | 5.56 | 7.85 | 4.6 | 5.75 | 10.92 |
Urinary tract | 4.17 | 8.82 | 3.92 | 5.39 | 4.17 | 9.8 | 7.84 | 3.92 | 6.13 | 11.76 | 2.7 |
Overexpression levels of the Na+/H+ exchanger (NHE) family members in cancer affecting several tissues.
Asterisks: also downregulated in some patients.
Overexpression >20% in bold letters.
n/a, not available.
(5%–10%).
(10%–15%).