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. 2021 Jan 24;11(8):2243–2264. doi: 10.1016/j.apsb.2021.01.012

Table 3.

Monocarboxylate-H+ co-transporters (MCTs) in cancer.

Cancer MCT1 MCT2 MCT3 MCT4 MCT5 MCT6 MCT8 MCT9 MCT10 MCT11 MCT12 MCT13 MCT14
Adrenal gland 1.27 29.11 1.27 2.53 29.11 3.8 2.53 1.27 2.53 10.13 3.8 8.86 20.25
Breast 6.79 2.9 1.36 8.33 2.99 5.53 7.7 2.54 4.35 3.35 2.36 7.34 4.62
CNS 4.45 3.59 5.02 4.88 5.6 4.45 5.02 3.16 2.58 4.43 2.15 4.02 3.16
Cervix 4.89 1.63 2.93 5.54 2.28 3.58 8.47 10.42 3.58 2.61 3.91 3.58 1.63
Endometrium 5.15 3.16 5.65 4.32 6.31 4.49 6.31 8.64a 9.47 5.15 4.98 7.14 6.64
Hematop. & Lymph. 2.26 5.43 2.26 4.52 11.31 4.07 5.43 21.72 4.52 4.98 4.52 3.17 3.17
Kidney 6.37 3 2.17 5.17 3.75 3.67 3.83 3.64 3.67 14.5 6 13.33 4.67
Large intestine 2.79 3.93 3.11 4.26 6.39 8.69 6.56 4.43 3.93 3.11 5.25 1.15 3.11
Liver 4.02 3.49 3.22 6.43 6.43 6.43 8.04 2.14 3.22 3.49 6.97 0.8 2.41
Lung 4.91 3.73 5.4 6.87 2.75 5.5 2.45 4.22 2.85 1.08 2.65 11.19 8.15
Oesophagus 6.4 5.6 9.6 0.8 0.8 9.6 12 3.2 5.6 1.6 11.2 10.4 10.4
Ovary 18.05 2.26 3.01 12.03 6.77 22.18 6.39 6.39 6.77 1.88 12.41 28.95b 4.14
Pancreas 2.76 3.35 9.5 5.59 6.15 6.15 2.79 10.06 2.79 9.5 7.82 11.17 6.15
Prostate 3.41 5.02 0.4 4.82 2.41 3.61 n/a 5.22 5.62 4.82 4.42 1.2 5.22
Skin 6.34 4.65 1.9 5.5 2.96 5.29 2.75 2.75 2.33 7.61 1.48 5.29 0.85
Soft tissue 3.42 1.9 0.76 4.94 1.52 4.18 5.7 4.36 9.89 2.66 2.28 4.94 9.13
Stomach 6.32 10.18 8.42 7.02 7.37 6.67 4.21 8.07 8.07 14.39 4.21 11.23 4.91
Thyroid 3.12 3.51 1.95 4.29 3.12 4.29 6.04 3.9 5.85 3.31 4.29 4.09 4.29
Upper aerodig. tract 5.36 3.26 2.49 4.79 1.15 6.7 10.15 4.02 4.6 3.26 2.68 7.09 6.13
Urinary tract 9.59 4.17 1.96 6.62 5.64 7.6 2.21 7.35 1.72 3.19 0.49 7.35 3.43

Overexpression levels of the monocarboxylate-H+ co-transporter (MCT) family members in cancer affecting several tissues.

Asterisks: also downregulated in some patients.

Overexpression >20% in bold letters.

n/a, not available.

a

(5%–10%).

b

(10%–15%).