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Built-in active MNs patch with enhanced drug delivery. (A) Schematic illustration of the design and mechanism of the active MNs patch. (B) Drug release kinetics of different MNs at pH 6.0. (C) Corresponding release percentage of aCTLA-4. (D) The fluorescence images of MNs patch obtained from top view. (i) Blank MNs, (ii) FITC-loaded MNs, and (iii) FITC-loaded active MNs. Scale bar, 1 mm. Reprinted with permission from Ref. 191. Copyright © 2019, John Wiley and Sons.
