Table 3.
Currently active clinical trials with MNs for therapeutic protein and peptide delivery.
| Condition or disease | Therapeutic agent | MNs type | CT phase | NCT identifier |
|---|---|---|---|---|
| Influenza | Inactivated influenza vaccine (IIV) | Dissolving MNs | 1 | NCT02438423 |
| Influenza | Trivalent influenza vaccine | Hollow MNs | 1/2 | NCT01707602 |
| Influenza | Intanza ® | A micro-needle injection system | 4 | NCT01368796 |
| Influenza | S-OIV H1N1 vaccine | MicronJet 600 (hollow MNs) | Not applicable | NCT01049490 |
| Influenza | Influenza vaccine (TIV 2010/2011) | Microneedle device (hollow MNs) | Not applicable | NCT01304563 |
| Influenza | Flu vaccine | Microneedle injectors (hollow MNs) | Not applicable | NCT00558649 |
| Healthy | H1N1 pandemic influenza | Microneedle device | Not applicable | NCT01039623 |
| Measles and Rubella | Measles rubella vaccine | Dissolving MNs | 1/2 | NCT04394689 |
| Renal Failure | HBV vaccine | A novel intradermal microneedle | 2/3 | NCT02621112 |
| Varicella Zoster infection | Zostavax | A novel intradermal microneedle | 2/3 | NCT02329457 |
| Atopic dermatitis | Fluzone® intradermal | An ultra-fine micro-needle | 1 | NCT01518478 |
| Atopic dermatitis | Fluzone® intradermal | An ultra-fine micro-needle | Not applicable | NCT01737710 |
| Intradermal injections | Insulin | MicronJet (hollow MNs) | 1 | NCT00602914 |
| Diabetes | Insulin | Hollow MNs | 1/2 | NCT01061216 |
| Diabetes | Insulin | Hollow MNs | 2/3 | NCT00837512 |
| Diabetes | C19-A3 GNP peptide | Nanopass microneedles | 1 | NCT02837094 |
| Diabetes | Insulin and glucagon | MicronJet (hollow MNs) | 2 | NCT01684956 |
| Hypoglycemia | Glucagon | Microneedle patch system | 1 | NCT02459938 |
| Postmenopausal osteoporosis | Abaloparatide | Solid microstructured transdermal system | 3 | NCT04064411 |
| Postmenopausal osteoporosis | Abaloparatide | Coated transdermal microarray | 2 | NCT01674621 |
| Postmenopausal osteoporosis | Zosano Pharma parathyroid hormone | Coated MNs | 1 | NCT02478879 |
| Primary axillary hyperhidrosis | Botulinum toxin type A | Fractional micro-needle radiofrequency | Not applicable | NCT03054480 |
| Poliomyelitis | Fractional IPV | MicronJet600 (hollow MNs) | 3 | NCT01813604 |
| Auto-immune/auto-inflammatory diseases | Adalimumab | MicronJet600 (hollow MNs) | 1/2 | NCT03607903 |