Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 3;4(11):e202101057. doi: 10.26508/lsa.202101057

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Beijer et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Figure 5. — (A) Subcellular fractions of patient (V335G) and control (cntr: healthy individual) fibroblasts treated with H₂O₂ to induce DNA damage, immunoblotted for α-tubulin (cytosolic control), H3 (nuclear control) and VDAC1 (mitochondrial control) in whole cell lysate, nuclear fraction (nucl), cytosolic fraction (cyto) and mitochrondial fraction (mito). (B, C) Quantification of ARH3 expression of V335G mutant relative to control (cntr: healthy individual) per fraction normalized to the respective subcellular fraction control α-tubulin/H3/α-tubulin/VDAC1 (n = 4, mean and SD) (C) quantification of panADPr signal of V335G mutant relative to control (cntr: healthy individual) per fraction normalized to the respective subcellular fraction control α-tubulin/H3 (n = 4, mean and SD).