Table 2.
Exosomal miRNA | Cancer type | Role in cancer metastasis | Ref. |
---|---|---|---|
miR-105 | Breast cancer | Down-regulate tight junction protein ZO-1 | 8 |
miR-122 | Breast cancer | Down-regulate glycolytic enzyme pyruvate kinase | 30 |
miR-19 | Breast cancer | PTEN loss | 31 |
miR-939 | Breast cancer | Inhibit VE-cadherin | 32 |
miR-21 | Lung cancer | Up-regulate STAT3 and VEGF | 33 |
miR-23a | Lung cancer | Down-regulate ZO-1 | 34 |
miR-21/29a | Lung cancer | Activating TLR7 and TLR8 | 35 |
miR-25-3p | Color rector cancer | Down-regulate ZO-1, occludin, and claudin5 | 27 |
miR-103 | Hepatocellular carcinoma | Down-regulate VE-Cadherin, p120, and ZO-1 | 29 |
miR-222-3p | Ovarian cancer | Down-regulate SOCS3 | 36 |