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. 2021 Apr 20;11(8):2136–2149. doi: 10.1016/j.apsb.2021.04.012

Table 2.

Various exosomal miRNAs in cancer metastasis.

Exosomal miRNA Cancer type Role in cancer metastasis Ref.
miR-105 Breast cancer Down-regulate tight junction protein ZO-1 8
miR-122 Breast cancer Down-regulate glycolytic enzyme pyruvate kinase 30
miR-19 Breast cancer PTEN loss 31
miR-939 Breast cancer Inhibit VE-cadherin 32
miR-21 Lung cancer Up-regulate STAT3 and VEGF 33
miR-23a Lung cancer Down-regulate ZO-1 34
miR-21/29a Lung cancer Activating TLR7 and TLR8 35
miR-25-3p Color rector cancer Down-regulate ZO-1, occludin, and claudin5 27
miR-103 Hepatocellular carcinoma Down-regulate VE-Cadherin, p120, and ZO-1 29
miR-222-3p Ovarian cancer Down-regulate SOCS3 36