Table 4.

Univariable and multivariable Cox models for survival after HCC.

	n	Univariable			Multivariable
		HR	95% CI	p value	HR	95% CI	p value
Gender
Female	120	1.00
Male	309	0.82	0.60–1.12	0.22
Age, years	430	0.99	0.85–1.14	0.85
BMI
<30 kg/m2	274	1.00
≧30 kg/m2	92	0.91	0.63–1.32	0.62
Diabetes
No	275	1.00
Yes	41	1.28	0.78–2.1	0.33
Smokers
Ex	101	1.00
Current	114	1.36	0.9–2.05	0.14
No	131	1.30	0.88–1.94	0.19
Comorbidities (obesity or diabetes or current smoker)
None	194	1.00
At least one	211	1.08	0.8–1.46	0.62
Aetiology of cirrhosis
Alcohol	95	1.00			1.00
Virus	273	0.62	0.44–0.87	0.006	1.06	0.64–1.78	0.80
Mixed	63	0.74	0.66–1.19	0.21	1.00	0.53–1.91	0.98
Multi nodule	160	1.00
Single nodule	245	0.52	0.39–0.71	<0.0001	0.94	0.63–1.41	0.77
Size of main nodule mm	377	1.03	1.02–1.04	<0.0001	1.02	1.00–1.03	0.003
AFP ng/ml	211	1.06	1.03–1.09	<0.0001	1.01	0.97–1.06	0.47
Performance status
0	278	1.00
1/ 2/ 3	51	4.39	2.96–6.53	<0.0001	1.84	1.02–3.23	0.045
Child-Pugh
A	294	1.00
B/C	66	3.36	2.35–4.81	<0.0001	2.31	1.50–3.58	<0.0001
BCLC
0–A	225	1.00
B–C–D	92	5.71	3.98–8.17	<0.0001	2.17	1.05–4.47	0.04
Platelets, G/L	244	1.00	0.99–1.0	0.25
Esophageal varices
Grade 0/1	290	1.00
Grade 2/3	141	1.52	1.13–2.05	0.005	1.08	0.75–1.53	0.69

Univariate comparisons use Fisher's exact test for categorical variables and Wilcoxon rank test for quantitative variables. Independant prognostic factors are indicated in bold. AFP, alpha-fetoprotein; BCLC, Barcleona Clinic Liver Cancer; HCC, hepatocellular carcinoma; HR, hazard ratio.