Table 3.
Single locus association analysis of CTLA-4 −1661 A/G SNP based on MVL and CVL subgroups.
| SNPs | Genetic Model | Genotype/allele | Control (n = 291) | Patients (n = 83) |
p-value OR (95%CI) |
|||
|---|---|---|---|---|---|---|---|---|
| MVL (n = 37) | CVL (n = 46) | MVL vs Control | CVL vs Control | CVL vs MVL | ||||
| CTLA-4 −1661A/G | Co-dominant | AA | 224 (77%) | 32 (86%) | 41 (89%) | Reference | Reference | Reference |
| AG | 63 (22%) | 5 (14%) | 5 (11%) | 0.101 | 0.064 | 0.844 | ||
| 0.40 (0.14–1.20) | 0.37 (0.13–1.06) | 0.87 (0.22–3.44) | ||||||
| GG | 4 (1%) | 0 (0%) | 0 (0%) | – | – | – | ||
| Dominant | AA | 224 (77%) | 32 (86%) | 41 (89%) | Reference | Reference | Reference | |
| AG + GG | 67 (23%) | 5 (14%) | 5 (11%) | 0.07 | 0.043 | 0.844 | ||
| 0.36 (0.12–1.08) | 0.33 (0.12–0.97) | 0.87 (0.22–3.44) | ||||||
| Recessive | AA + AG | 287 (98%) | 37 (100%) | 47 (100%) | Reference | Reference | Reference | |
| GG | 4 (2%) | 0 (0%) | 0 (0%) | – | – | – | ||
| Overdominant | AA + GG | 228 (78%) | 32 (86%) | 41 (89%) | Reference | Reference | Reference | |
| AG | 63 (22%) | 5 (14%) | 5 (11%) | 0.114 | 0.071 | 0.844 | ||
| 0.42 (0.14–1.23) | 0.38 (0.13–1.09) | 0.87 (0.22–3.44) | ||||||
| Additive | A | 511 (88%) | 69 (93%) | 87 (95%) | Reference | Reference | Reference | |
| G | 71 (12%) | 5 (7%) | 5 (5%) | 0.059 | 0.036 | 0.850 | ||
| 0.37 (0.13–1.03) | 0.34 (0.12–0.93) | 0.88 (0.23–3.31) | ||||||
n, number of samples(% distribution); MVL-Mitral valve lesion; CVL-Combined valve lesion. p-value and odds ratio (OR) were calculated by performing multivariate logistic regression analysis after adjustment for age and gender by using SPSS version 16.0. Significance was maintained at p < 0.05 after FDR correction.
The p values written in bold are statistically significant values.