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Strategies for long-acting parenteral formulations. (A) Chemical modification. (B) Fc/HSA fusion. (C) Cell-mediated biomimetic strategies. (D) Micro-encapsulation. (E) DepoFoamTM technology. (F) Oil-based formulation. (G) NanoCrystal technology. (H) Biomineralization. (I) Long-acting hydrogels. (J) Long-acting microneedles. (K) Long-acting implantable systems.
