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. 2021 Mar 13;11(8):2362–2395. doi: 10.1016/j.apsb.2021.03.019

Figure 14.

Figure 14

Pharmacokinetic characteristic of MOFs (A/B) and drugs loaded in MOFs(C/D) (A) Assessment of salicylate elimination (black) and MIL-127 matrix degradation (red) under simulated GI environment. Different acetylsalicylic acid: MIL-127 ratios were studied: 3:1 (triangles) and 1.5:1 (circles). Reprinted with permission from Ref. 263. Copyright © 2018, American Chemical Society (B) Biodistribution. (a) Levels of BTC in major organs and urine (b) mg of BTC per g of major organ. Reprinted with permission from Ref. 32. Copyright © 2016, Elsevier (C) Plasma concentration–time curves of AZL in rats after oral administration. Reprinted with permission from Ref. 20. Copyright © 2019, Elsevier (D) Biodistribution of RhoB-labeled insulin in the bodies of the mice (a), livers (b), kidneys (c) after the oral administration at different time points. Reprinted with permission from Ref. 273. Copyright © 2020, American Chemical Society.