Table 1.

Classification of MOFs by metal ions and their molecular pore size for drug loading.

Genre	Naming	Organic linker	Pore size (Å)	Drug loading	Ref.
Fe-MOFs	MIL-89 (Fe)	Muconic acid	11	Ibuprofen, azidothymidine triphosphate	57
	MIL-88A (Fe)	Fumaric acid	6	Ibuprofen, cidofovir	57
	MIL-100 (Fe)	1,3,5-Benzenetricarboxylic acid	25, 29	Gemcitabine-monophosphate, topotecan, isoniazid, doxycycline, tetracycline, docetaxel, azidothymidine triphosphate, lamivudine triphosphate	57,62,68,70‒72
	MIL-101_NH2 (Fe)	Amino 1,4-benzenedicarboxylic acid	29, 34	Azidothymidine triphosphate, cidofovir, ethoxysuccinato-cisplatin	57,73
	MIL-53 (Fe)	1,4-Benzenedicarboxylic acid	8.6	Ibuprofen, oridonin	50,63
	MIL-101 (Fe)	2-Amino 1,4-benzenedicarboxylic acid	25–30	Ibuprofen, azidothymidine triphosphate	57
	MIL-127	3,3ʹ,5,5ʹ-Azobenzenetetracarboxylate	4	Caffeine	74
Zn-MOFs	Zn (TATAT)2/3 ·3DMF·H2O	TATAT = 5,5ʹ,5ʹʹ-(1,3,5-Triazine-2,4,6-triyl) Tris (azanediyl)triisophthalate	17, 21	5-Fluorouracil	75
	ZnBDP_X	1,4-Bis(1H-pyrazol-4-yl)-2-X-benzene (H2BDP_X; X = H, NO2, NH2, OH)	11	Mitoxantrone	64
	Bio-MOFs	Azobenzene-4,4ʹ-dicarboxylic acid and biphenyl-4,4ʹ-dicarboxylic acid	8.3–26	Etilefrine hydrochloride	76
	Zn8(O)2(CDDB)6 (DMF)4(H2O)	4,4ʹ-(9-H-Carbazole-3,6-diyl) dibenzoic acid	28.1 × 23.17	5-Fluorouracil	65
	ZIF-8	2-Methylimidazolate	11.6	5-Fluorouracil, doxorubicin	77,78
Zr-MOFs	UiO-66	1,4-Benzenedicarboxylic acid	8	Caffeine, dichloroacetate	53,74
	UiO NMOFs	Amino-triphenyldicarboxylic acid	–	Cisplatin prodrug, siRNAs	79
	UiO-66-NH2/NO2	1,4-Benzenedicarboxylic acid	–	Ketoprofen	66
K-MOFs	CD-MOF-1	Cyclodextrins	4–17	Lansoprazole, azilsartan, budesonide, valsartan	20,67,68,80
Cu-MOFs	HKUST-1	1,3,5-Benzenetricarboxylic acid	14.67	Ibuprofen	69
	MOF-2/MOF-3	1,3,5-Benzenetricarboxylic acid and isophthalic acid	21.2/20.9	Ibuprofen, doxorubicin hydrochloride	69

‒, not applicable.