Table 5.

Current challenges and potential suggestions for MOFs-based DDS.

Challenge	Suggestion
In vivo fates of MOFs and drugs loaded inside are unclear	• Choosing the appropriate animal model as preclinical evaluation • Optimizing the preparations and administration routes
Current researches are limited to qualitative evaluation of MOFs	• Paying attention to quantitative quality control strategies for contents of MOFs • Limiting starting materials for impurities control
Some MOFs are unstable in physiological conditions	• Surface functionalization of MOFs • Combination with other more stable materials
Lack of systematic biosafety evaluation to MOFs	• Selecting metal ions and organic linkers with favorable biocompatibility • Highlighting the pharmacokinetics mechanism as the whole ADME process
No established standard for MOFs classification and nomenclature	• Unifying the naming rules of MOFs