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Residues 73 to 333 of the DNA ligase III cDNA encode a functional mitochondrial targeting sequence. Confocal images show Cos-1 cells transfected with plasmid pCOXVIII-GFP (A), Cos-1 cells transfected with pLIG3-GFP-2 (B), and untransfected Cos-1 cells (C) stained with 3 μM JC-1, a fluorescent dye that specifically stains mitochondria.
