Table 3.

Change in International Index of Erectile Function (IIEF) and Sex Hormone Levels

	Model Based Estimates, Mean (SD)					Model Based Mean Change (95% CI)				P-Value
	Baseline	Year 1	Year 2	Year 3	Year 4	Year 1 from Baseline	Year 2 from Baseline	Year 3 from Baseline	Year 4 from Baseline	Year 1 vs Baseline	Year 2 vs Baseline	Year 3 vs Baseline	Year 4 vs Baseline
IIEF Scores
Erectile function	19.9 (11.6)	21.3 (10.4)	24.4 (8.5)	23.1 (10.2)	23.1 (9.4)	1.4 (−4.0, 6.8)	4.5 (−0.6, 9.6)	3.2 (−2.0, 8.4)	3.1 (−2.3, 8.6)	0.910	0.099	0.357	0.395
Orgasmic function	7.1 (3.9)	7.2 (4.0)	8.7 (2.7)	8.1 (3.3)	7.6 (3.8)	0.1 (−2.1, 2.4)	1.6 (−0.3, 3.5)	1.0 (−0.9, 3.0)	0.6 (−1.7, 2.8)	>0.99	0.113	0.490	0.926
Sexual desire	6.4 (2.5)	7.6 (2.2)	7.5 (1.9)	7.1 (2.2)	7.5 (2.3)	1.2 (−0.0, 2.4)	1.1 (−0.0, 2.2)	0.7 (−0.5, 1.8)	1.1 (−0.2, 2.3)	0.058	0.057	0.423	0.118
Intercourse satisfaction	7.3 (5.6)	8.5 (5.2)	9.0 (4.9)	9.0 (5.0)	8.7 (5.0)	1.2 (−1.6, 3.9)	1.7 (−0.9, 4.4)	1.7 (−0.9, 4.3)	1.4 (−1.3, 4.1)	0.672	0.308	0.281	0.531
Overall satisfaction	6.1 (2.8)	7.0 (2.6)	7.2 (2.8)	7.6 (2.4)	6.8 (2.5)	0.9 (−0.4, 2.2)	1.1 (−0.3, 2.4)	1.5 (0.3, 2.7)	0.7 (−0.6, 2.0)	0.266	0.171	0.008	0.499
Sex Hormone Levels
Total testosterone, ng/dL	317.1 (112.1)	495.5 (185.8)	508.7 (149.7)	470.0 (137.7)	432.8 (108.5)	178.4 (99.1, 257.8)	191.6 (121.0, 262.2)	152.9 (84.3, 221.6)	115.7 (52.9, 178.6)	<.001	<.001	<.001	<.001
Free testosterone, pg/mL	7.7 (2.5)	10.1 (5.4)	8.5 (2.6)	8.5 (3.1)	8.0 (2.4)	2.4 (0.0, 4.7)	0.8 (−0.5, 2.1)	0.7 (−0.8, 2.3)	0.3 (−1.1, 1.7)	0.045	0.361	0.582	0.963
LH, miu/mL	3.8 (3.2)	6.3 (7.7)	7.8 (10.4)	6.8 (10.8)	6.5 (8.3)	2.5 (0.3, 4.8)	4.0 (0.5, 7.5)	3.0 (−0.7, 6.7)	2.6 (−0.1, 5.4)	0.024	0.024	0.136	0.063
SHBG, nmol/L	21.6 (8.1)	60.3 (22.3)	64.1 (19.4)	66.6 (14.4)	60.6 (16.0)	38.7 (30.0, 47.4)	42.5 (34.7, 50.3)	45.0 (39.2, 50.9)	39.0 (32.0, 46.1)	<.001	<.001	<.001	<.001